LUO ZHEN       Research associate Research direction: Molecular Nutrient and Development of plant active ingredients  Email：luozhen0615@sjtu.edu.cn

 

Zhen Luo, PhD in Biology from Shanghai Jiao Tong University in 2019, has worked as a postdoctoral researcher in the School of Medicine and the School of Agriculture and Biology of Shanghai Jiao Tong University. Her research interests include molecular mechanism of oxidative stress and nutrient regulation, and development of plant active ingredients. Has published more than 20 papers in renowned international journals such as the Journal of Translational Medicine, Animal Nutrition, Ecotoxicology and Environmental Safety, American Journal of Physiology-Cell Physiology during last 5 years, won the second Prize of Shanghai Science and Technology Progress Award in 2017 and the second Prize of China Industry-University-Research Cooperation Innovation Achievement Award in 2018.

 

Projects：

2020.07-2022.08 China Postdoctoral Science Foundation: The molecular mechanism of PINK1/Parkin pathway regulating mitochondrial function in porcine placenta

 

2021.07-2024.09 Shanghai modern seed industry collaborative innovation center cultivation project: Functional mining of NIPSNAP in intramuscular fat deposition and pork quality formation in pigs 

 

Publications:

1、Luo Z, Yao J, Wang Z, Xu J*. Mitochondria in endothelial cells angiogenesis and function: current understanding and future perspectives. Journal of Translational Medicine 21, 441 (2023). https://doi.org/10.1186/s12967-023-04286-1.

2、Luo Z, Gao Q, Li Y, Bai Y, Zhang J, Xu W, Xu J*. Flammulina velutipes Mycorrhizae Attenuate High Fat Diet Induced Lipid Disorder, Oxidative Stress and Inflammation in the Liver and Perirenal Adipose Tissue of Mice. Nutrients 2022, 14, 3830. https://doi.org/10.3390/nu14183830.

3、Shen C#, Luo Z#, Ma S, Yu C, Gao Q, Zhang M, Zhang H, Zhang J, Xu W, Yao J and Xu J*. Microbe-Derived Antioxidants Reduce Lipopolysaccharide Induced Inflammatory Responses by Activating the Nrf2 Pathway to Inhibit the ROS/NLRP3/IL-1β Signaling Pathway. International Journal of Molecular Sciences 2022, 23, 12477. https://doi.org/10.3390/ijms232012477.

4、Luo Z, Gao Q, Zhang H, Zhang Y, Zhou S, Zhang J, Xu W, Xu J*. Microbe-derived antioxidants attenuate cobalt chloride-induced mitochondrial function, autophagy and BNIP3-dependent mitophagy pathways in BRL3A cells. Ecotoxicology and Environmental Safety, 2022, 232113219.

5、Luo Z, Yao J, Xu J*. Reactive oxygen and nitrogen species regulate porcine embryo development during preimplantation period: A mini-review. Animal Nutrition, 2021, 7(3):823-828.

6、Luo Z, Xu X, Sho T, Zhang J, Xu W, Yao J, Xu J*. ROS-induced autophagy regulates porcine trophectoderm cell apoptosis, proliferation and differentiation. American Journal of Physiology-Cell Physiology, 2019, 316:2, C198-C209.

7、Luo Z, Xu X, Sho T, Luo W, Zhang J, Xu W, Yao J, Xu J*. Effects of N-acetyl-cysteine in late gestational diet on maternal-placental redox status, placental NLRP3 inflammasome and fecal microbiota in sows. Journal of Animal Science, 2019. 97(4), 1757-1771.

8、Luo Z, Luo W, Li S, Zhao S, Sho T, Xu X, Zhang J, Xu W, Xu J*. Reactive oxygen species mediated placental oxidative stress, mitochondrial content, and cell cycle progression through mitogen-activated protein kinases in intrauterine growth restricted pigs. Reproductive Biology, 2018, 18(4), 422-431.

9、Luo Z, Zhu W, Guo Q, Luo W, Zhang J, Xu W, Xu J*. Weaning induced hepatic oxidative stress, apoptosis, and aminotransferases through MAPK signaling pathways in piglets. Oxidative Medicine and Cell Longevity, 2016(9), 4768541.

 

Awards：

Second Prize of Shanghai Science and Technology Progress Award in 2017;

Second Prize of China Industry-University-Research Cooperation Innovation Achievement Award in 2018.