报告题目：类固醇受体共激活因子2介导的T细胞免疫应答

报告摘要：

类固醇受体共激活因子 (SRC) 家族由三个成员组成，SRC1、SRC2和 SRC3， 它们通过共激活转录因子来调节基因转录，广泛参与多个生物学过程并发挥重要作用。早期的研究表明，SRC 家族在多种恶性肿瘤中存在异常表达，且与肿瘤细胞的增殖、迁移、侵袭以及耐药有关，因此被认为是抗癌治疗的潜在靶点。最近的研究发现，SRC 在T 细胞分化和功能中也发挥重要调控作用。报告人主要介绍SRC的基本结构和功能，SRC2在T细免疫应答中的关键作用，并探讨靶向SRC2在抗肿瘤免疫、抗感染免疫及自身免疫异常中的潜在可能。

报告人简介：

 张文灿，2019年博士毕业于新加坡国立大学（National University of Singapore）， 2019-2023年于美国希望之城国家医学中心 (City of Hope National Medical Center) 从事博士后研究。2024年1月加入上海交通大学。长期聚焦免疫学、分子生物学及食品科学，共发表SCI论文18篇，其中第一作者文章12篇，包括PNAS, Science Advances, Food Research International等。

【所在学科研究组研究方向】：

课题组聚焦动物科学与免疫调控，研究方向涉及：

1）病原微生物与适应性免疫系统的互作机制;

2) T细胞的分化调控及其介导的免疫响应；

3）家畜炎性疾病的发病机理及药物开发。

【代表性著作】

1. Zhang, W., Cao, X., Zhong, X., Wu, H., Shi, Y., & Sun, Z. (2024). Regulatory function of steroid receptor coactivators (SRCs) in cell metabolism: implications for cancer and immunity. Critical Reviews in Immunology.

2. Zhang, W., Cao, X., Zhong, X., Wu, H., Shi, Y., Feng, M., Wang, Y., Ann, D., Gwack Y., Shang, W., & Sun, Z. (2023). SRC2 controls CD4+ T cell activation via stimulating c-Myc mediated up-regulation of amino acid transporter Slc7a5. Proceedings of the National Academy of Sciences (PNAS), 120(18), e2221352120

3. Zhang, W., Cao, X., Zhong, X., Wu, H., Feng, M., Gwack Y., & Sun, Z. (2022). Steroid nuclear receptor coactivator 2 controls immune tolerance by promoting induced Treg differentiation via upregulating Nr4a2. Science Advances, 8 (24), eabn7662.

ACADEMIC SALON (LI)

SPEAKER: WENCAN ZHANG

                 Tenure-track Associate Professor, Ph.D.

                  Department of Animal Science, SAB

TIME ：12:40-14:00 Jun 5, 2024 (Wed)

VENUE：Room 104, Building B, SAB

ORGANIZER：Office of Discipline and Science & Technology, SAB;

                         Young Teachers Association, SAB

TITLE： Steroid receptor coactivator 2 mediated T cell immunity

ABSTRACT：

The steroid receptor coactivator (SRC) family consists of three members, SRC1, SRC2, and SRC3, which regulate gene transcription by coactivating transcription factors, and are widely involved in several biological processes. Early studies have shown that the SRC family is abnormally expressed in a variety of malignancies and is related to the proliferation, migration, invasion and drug resistance of tumor cells. Thus, it is considered as a potential target for anti-cancer therapy. Recent studies have found that SRC also plays an important role in T cell differentiation and function. In the current presentation, the presenter will briefly introduce the basic background of SRCs, the key function of SRC2 in T cell-mediated immune responses, and explore the possibility of targeting SRC2 in immunotherapy for anti-tumor, anti-infection and autoimmune disorders.